BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor.
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| Title: | BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor. |
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| Authors: | Rianjongdee F; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Atkinson SJ; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Bamborough P; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Barnett HA; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Friston K; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Grandi P; Cellzome, GlaxoSmithKline, Meyerhofstr. 1, Heidelberg 69117, Germany., Neipp CE; GSK, South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States., Petretich M; Cellzome, GlaxoSmithKline, Meyerhofstr. 1, Heidelberg 69117, Germany., Phillipou A; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Preston AGS; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Prinjha RK; GSK, Stevenage, Hertfordshire SG1 2NY, U.K., Tomkinson NCO; Department for Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, U.K., Demont EH; GSK, Stevenage, Hertfordshire SG1 2NY, U.K. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2026 Jan 22; Vol. 69 (2), pp. 895-917. Date of Electronic Publication: 2025 Dec 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41467648 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rianjongdee+F%22">Rianjongdee F</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Atkinson+SJ%22">Atkinson SJ</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Bamborough+P%22">Bamborough P</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Barnett+HA%22">Barnett HA</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Friston+K%22">Friston K</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Grandi+P%22">Grandi P</searchLink>; Cellzome, GlaxoSmithKline, Meyerhofstr. 1, Heidelberg 69117, Germany.<br /><searchLink fieldCode="AU" term="%22Neipp+CE%22">Neipp CE</searchLink>; GSK, South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.<br /><searchLink fieldCode="AU" term="%22Petretich+M%22">Petretich M</searchLink>; Cellzome, GlaxoSmithKline, Meyerhofstr. 1, Heidelberg 69117, Germany.<br /><searchLink fieldCode="AU" term="%22Phillipou+A%22">Phillipou A</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Preston+AGS%22">Preston AGS</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Prinjha+RK%22">Prinjha RK</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Tomkinson+NCO%22">Tomkinson NCO</searchLink>; Department for Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, U.K.<br /><searchLink fieldCode="AU" term="%22Demont+EH%22">Demont EH</searchLink>; GSK, Stevenage, Hertfordshire SG1 2NY, U.K. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jan 22; Vol. 69 (2), pp. 895-917. <i>Date of Electronic Publication: </i>2025 Dec 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41467648 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.5c00622 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 895 Titles: – TitleFull: BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rianjongdee F – PersonEntity: Name: NameFull: Atkinson SJ – PersonEntity: Name: NameFull: Bamborough P – PersonEntity: Name: NameFull: Barnett HA – PersonEntity: Name: NameFull: Friston K – PersonEntity: Name: NameFull: Grandi P – PersonEntity: Name: NameFull: Neipp CE – PersonEntity: Name: NameFull: Petretich M – PersonEntity: Name: NameFull: Phillipou A – PersonEntity: Name: NameFull: Preston AGS – PersonEntity: Name: NameFull: Prinjha RK – PersonEntity: Name: NameFull: Tomkinson NCO – PersonEntity: Name: NameFull: Demont EH IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 01 Text: 2026 Jan 22 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 69 – Type: issue Value: 2 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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