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Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations.

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Bibliographic Details
Title: Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations.
Authors: Pinheiro F; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain., Kant R; Department of Chemistry, Washington University, St. Louis, MO 63130., Chemuru S; Department of Chemistry, Washington University, St. Louis, MO 63130., Varejão N; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain., Velázquez-Campoy A; Faculty of Sciences, Department of Biochemistry and Molecular and Cellular Biology, Institute of Biocomputation and Physics of Complex Systems, Universidad de Zaragoza, Zaragoza 50018, Spain.; Institute for Health Research Aragon (Instituto de Investigación Sanitaria Aragón), Zaragoza 50009, Spain.; Networking Biomedical Research Centre in Liver and Digestive Diseases, Madrid 28029, Spain.; Department of Biochemistry and Molecular and Cell Biology, University of Zaragoza, Zaragoza 50009, Spain., Reverter D; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain., Pallarès I; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain., Gross ML; Department of Chemistry, Washington University, St. Louis, MO 63130., Ventura S; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain.; Institut d'Investigació i Innovació Parc Taulí - Catalan Network of Research Centers, Sabadell 08208, Spain.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 06; Vol. 123 (1), pp. e2519908122. Date of Electronic Publication: 2025 Dec 31.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2519908122