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A Placebo-Controlled Exploratory Trial of Sirolimus for Tocilizumab-Resistant Idiopathic Multicentric Castleman Disease: Early Termination and Long-Term Extension Results Based on Descriptive Results From Two Patients.

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Title: A Placebo-Controlled Exploratory Trial of Sirolimus for Tocilizumab-Resistant Idiopathic Multicentric Castleman Disease: Early Termination and Long-Term Extension Results Based on Descriptive Results From Two Patients.
Authors: Koga T; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN., Sumiyoshi R; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN., Shimizu T; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN., Hosogaya N; Clinical Research Center, Nagasaki University Hospital, Nagasaki, JPN., Fukushima C; Clinical Research Center, Nagasaki University Hospital, Nagasaki, JPN., Yamamoto H; Clinical Research Center, Nagasaki University Hospital, Nagasaki, JPN., Yoshifuji H; Department of Rheumatology and Clinical Immunology, Kyoto University, Kyoto, JPN., Higa S; Department of Internal Medicine, Division of Rheumatology, Daini Osaka Police Hospital, Osaka, JPN., Kawakami A; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.
Source: Cureus [Cureus] 2025 Dec 01; Vol. 17 (12), pp. e98233. Date of Electronic Publication: 2025 Dec 01 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A Placebo-Controlled Exploratory Trial of Sirolimus for Tocilizumab-Resistant Idiopathic Multicentric Castleman Disease: Early Termination and Long-Term Extension Results Based on Descriptive Results From Two Patients.
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  Data: <searchLink fieldCode="AU" term="%22Koga+T%22">Koga T</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.<br /><searchLink fieldCode="AU" term="%22Sumiyoshi+R%22">Sumiyoshi R</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.<br /><searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.<br /><searchLink fieldCode="AU" term="%22Hosogaya+N%22">Hosogaya N</searchLink>; Clinical Research Center, Nagasaki University Hospital, Nagasaki, JPN.<br /><searchLink fieldCode="AU" term="%22Fukushima+C%22">Fukushima C</searchLink>; Clinical Research Center, Nagasaki University Hospital, Nagasaki, JPN.<br /><searchLink fieldCode="AU" term="%22Yamamoto+H%22">Yamamoto H</searchLink>; Clinical Research Center, Nagasaki University Hospital, Nagasaki, JPN.<br /><searchLink fieldCode="AU" term="%22Yoshifuji+H%22">Yoshifuji H</searchLink>; Department of Rheumatology and Clinical Immunology, Kyoto University, Kyoto, JPN.<br /><searchLink fieldCode="AU" term="%22Higa+S%22">Higa S</searchLink>; Department of Internal Medicine, Division of Rheumatology, Daini Osaka Police Hospital, Osaka, JPN.<br /><searchLink fieldCode="AU" term="%22Kawakami+A%22">Kawakami A</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.
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  Data: <searchLink fieldCode="JN" term="%22101596737%22">Cureus</searchLink> [Cureus] 2025 Dec 01; Vol. 17 (12), pp. e98233. <i>Date of Electronic Publication: </i>2025 Dec 01 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cureus%2C+Inc%22">Cureus, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101596737 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2168-8184 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221688184%22">21688184 </searchLink><i>NLM ISO Abbreviation: </i>Cureus <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.7759/cureus.98233
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        Text: English
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      – TitleFull: A Placebo-Controlled Exploratory Trial of Sirolimus for Tocilizumab-Resistant Idiopathic Multicentric Castleman Disease: Early Termination and Long-Term Extension Results Based on Descriptive Results From Two Patients.
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              Text: 2025 Dec 01
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