An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.

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Title: An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.
Authors: Loberg MA; Department of Pathology, Microbiology, and Immunology., Xu GJ; Department of Pathology, Microbiology, and Immunology., Chen SC; Department of Biostatistics., Chen HC; Department of Biostatistics., Wahoski CC; Department of Pathology, Microbiology, and Immunology., Caroland KP; Department of Pathology, Microbiology, and Immunology., Tigue ML; Department of Pathology, Microbiology, and Immunology., Hartmann HA; Department of Pathology, Microbiology, and Immunology., Gallant JN; Department of Otolaryngology - Head and Neck Surgery; and., Phifer CJ; Department of Pathology, Microbiology, and Immunology., Ocampo AA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Fankhauser RG; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Karunakaran KA; Department of Pathology, Microbiology, and Immunology., Wu CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Tarabichi M; The Francis Crick Institute, London, United Kingdom.; Institute of Interdisciplinary Research (IRIBHM), Universite Libre de Bruxelles, Brussels, Belgium., Shaddy SM; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Netterville JL; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Ingram Cancer Center and., Rohde SL; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Ingram Cancer Center and., Solórzano CC; Vanderbilt Ingram Cancer Center and.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Bischoff LA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Baregamian N; Vanderbilt Ingram Cancer Center and.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Murphy BA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Ingram Cancer Center and., Choe JH; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang JR; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Huang EC; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Sheng Q; Department of Biostatistics., Kagohara LT; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University, Baltimore, Maryland, USA.; Bloomberg-Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jaffee EM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University, Baltimore, Maryland, USA.; Bloomberg-Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Belcher RH; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Division of Pediatric Otolaryngology - Head and Neck Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA., Lau KS; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ye F; Department of Biostatistics., Lee E; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA., Weiss VL; Department of Pathology, Microbiology, and Immunology.; Vanderbilt Ingram Cancer Center and.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
Source: JCI insight [JCI Insight] 2026 Jan 09; Vol. 11 (1). Date of Electronic Publication: 2026 Jan 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.191990