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An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.

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Title: An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.
Authors: Loberg MA; Department of Pathology, Microbiology, and Immunology., Xu GJ; Department of Pathology, Microbiology, and Immunology., Chen SC; Department of Biostatistics., Chen HC; Department of Biostatistics., Wahoski CC; Department of Pathology, Microbiology, and Immunology., Caroland KP; Department of Pathology, Microbiology, and Immunology., Tigue ML; Department of Pathology, Microbiology, and Immunology., Hartmann HA; Department of Pathology, Microbiology, and Immunology., Gallant JN; Department of Otolaryngology - Head and Neck Surgery; and., Phifer CJ; Department of Pathology, Microbiology, and Immunology., Ocampo AA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Fankhauser RG; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Karunakaran KA; Department of Pathology, Microbiology, and Immunology., Wu CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Tarabichi M; The Francis Crick Institute, London, United Kingdom.; Institute of Interdisciplinary Research (IRIBHM), Universite Libre de Bruxelles, Brussels, Belgium., Shaddy SM; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Netterville JL; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Ingram Cancer Center and., Rohde SL; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Ingram Cancer Center and., Solórzano CC; Vanderbilt Ingram Cancer Center and.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Bischoff LA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Baregamian N; Vanderbilt Ingram Cancer Center and.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Murphy BA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Ingram Cancer Center and., Choe JH; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang JR; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Huang EC; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Sheng Q; Department of Biostatistics., Kagohara LT; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University, Baltimore, Maryland, USA.; Bloomberg-Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jaffee EM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University, Baltimore, Maryland, USA.; Bloomberg-Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Belcher RH; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Division of Pediatric Otolaryngology - Head and Neck Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA., Lau KS; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ye F; Department of Biostatistics., Lee E; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA., Weiss VL; Department of Pathology, Microbiology, and Immunology.; Vanderbilt Ingram Cancer Center and.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
Source: JCI insight [JCI Insight] 2026 Jan 09; Vol. 11 (1). Date of Electronic Publication: 2026 Jan 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.
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  Data: <searchLink fieldCode="AU" term="%22Loberg+MA%22">Loberg MA</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Xu+GJ%22">Xu GJ</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Department of Biostatistics.<br /><searchLink fieldCode="AU" term="%22Chen+HC%22">Chen HC</searchLink>; Department of Biostatistics.<br /><searchLink fieldCode="AU" term="%22Wahoski+CC%22">Wahoski CC</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Caroland+KP%22">Caroland KP</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Tigue+ML%22">Tigue ML</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Hartmann+HA%22">Hartmann HA</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Gallant+JN%22">Gallant JN</searchLink>; Department of Otolaryngology - Head and Neck Surgery; and.<br /><searchLink fieldCode="AU" term="%22Phifer+CJ%22">Phifer CJ</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Ocampo+AA%22">Ocampo AA</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wang+DK%22">Wang DK</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Fankhauser+RG%22">Fankhauser RG</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Karunakaran+KA%22">Karunakaran KA</searchLink>; Department of Pathology, Microbiology, and Immunology.<br /><searchLink fieldCode="AU" term="%22Wu+CC%22">Wu CC</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Tarabichi+M%22">Tarabichi M</searchLink>; The Francis Crick Institute, London, United Kingdom.; Institute of Interdisciplinary Research (IRIBHM), Universite Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Shaddy+SM%22">Shaddy SM</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Netterville+JL%22">Netterville JL</searchLink>; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Ingram Cancer Center and.<br /><searchLink fieldCode="AU" term="%22Rohde+SL%22">Rohde SL</searchLink>; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Ingram Cancer Center and.<br /><searchLink fieldCode="AU" term="%22Solórzano+CC%22">Solórzano CC</searchLink>; Vanderbilt Ingram Cancer Center and.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Bischoff+LA%22">Bischoff LA</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Baregamian+N%22">Baregamian N</searchLink>; Vanderbilt Ingram Cancer Center and.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+BA%22">Murphy BA</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Ingram Cancer Center and.<br /><searchLink fieldCode="AU" term="%22Choe+JH%22">Choe JH</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wang+JR%22">Wang JR</searchLink>; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Huang+EC%22">Huang EC</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Sheng+Q%22">Sheng Q</searchLink>; Department of Biostatistics.<br /><searchLink fieldCode="AU" term="%22Kagohara+LT%22">Kagohara LT</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University, Baltimore, Maryland, USA.; Bloomberg-Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Jaffee+EM%22">Jaffee EM</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University, Baltimore, Maryland, USA.; Bloomberg-Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Belcher+RH%22">Belcher RH</searchLink>; Department of Otolaryngology - Head and Neck Surgery; and.; Vanderbilt Division of Pediatric Otolaryngology - Head and Neck Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Lau+KS%22">Lau KS</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Ye+F%22">Ye F</searchLink>; Department of Biostatistics.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+VL%22">Weiss VL</searchLink>; Department of Pathology, Microbiology, and Immunology.; Vanderbilt Ingram Cancer Center and.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Jan 09; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Jan 09 (<i>Print Publication: </i>2026).
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