Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.

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Title: Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.
Authors: Nambu R; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan. nambee1231@gmail.com., Iwama I; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan., Takeuchi I; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan., Hagiwara SI; Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan., Etani Y; Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan., Kaji E; Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan., Yoden A; Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.; Department of Pediatrics, Kawanishi City Medical Center, Hyogo, Japan., Kakuta F; Department of Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan., Hoshi Y; Department of Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan., Tsumura N; Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan., Mizuochi T; Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan., Kumagai H; Department of Pediatrics, Jichi Medical University, Tochigi, Japan., Yokoyama K; Department of Pediatrics, Jichi Medical University, Tochigi, Japan., Nishizawa T; Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan., Usami M; Department of Pediatrics School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan., Takaki Y; Department of Pediatric Gastroenterology and Hepatology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan., Ebana R; Department of Pediatrics, Okinawa Chubu Hospital, Okinawa, Japan., Kurasawa S; Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan., Fujikawa H; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Ishige T; Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan., Kudo T; Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan., Yoshida MM; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan., Shimizu H; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan., Arai K; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Source: Journal of gastroenterology [J Gastroenterol] 2026 Apr; Vol. 61 (4), pp. 398-409. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1435-5922
DOI:10.1007/s00535-025-02334-9