Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.

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Title: Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.
Authors: Nambu R; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan. nambee1231@gmail.com., Iwama I; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan., Takeuchi I; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan., Hagiwara SI; Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan., Etani Y; Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan., Kaji E; Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan., Yoden A; Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.; Department of Pediatrics, Kawanishi City Medical Center, Hyogo, Japan., Kakuta F; Department of Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan., Hoshi Y; Department of Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan., Tsumura N; Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan., Mizuochi T; Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan., Kumagai H; Department of Pediatrics, Jichi Medical University, Tochigi, Japan., Yokoyama K; Department of Pediatrics, Jichi Medical University, Tochigi, Japan., Nishizawa T; Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan., Usami M; Department of Pediatrics School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan., Takaki Y; Department of Pediatric Gastroenterology and Hepatology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan., Ebana R; Department of Pediatrics, Okinawa Chubu Hospital, Okinawa, Japan., Kurasawa S; Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan., Fujikawa H; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Ishige T; Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan., Kudo T; Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan., Yoshida MM; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan., Shimizu H; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan., Arai K; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Source: Journal of gastroenterology [J Gastroenterol] 2026 Apr; Vol. 61 (4), pp. 398-409. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Nambu+R%22">Nambu R</searchLink>; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan. nambee1231@gmail.com.<br /><searchLink fieldCode="AU" term="%22Iwama+I%22">Iwama I</searchLink>; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+I%22">Takeuchi I</searchLink>; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hagiwara+SI%22">Hagiwara SI</searchLink>; Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Etani+Y%22">Etani Y</searchLink>; Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kaji+E%22">Kaji E</searchLink>; Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yoden+A%22">Yoden A</searchLink>; Department of Pediatrics, Osaka Medical and Pharmaceutical University, Osaka, Japan.; Department of Pediatrics, Kawanishi City Medical Center, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Kakuta+F%22">Kakuta F</searchLink>; Department of Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Hoshi+Y%22">Hoshi Y</searchLink>; Department of Gastroenterology, Miyagi Children's Hospital, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Tsumura+N%22">Tsumura N</searchLink>; Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuochi+T%22">Mizuochi T</searchLink>; Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Kumagai+H%22">Kumagai H</searchLink>; Department of Pediatrics, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Yokoyama+K%22">Yokoyama K</searchLink>; Department of Pediatrics, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Nishizawa+T%22">Nishizawa T</searchLink>; Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan.<br /><searchLink fieldCode="AU" term="%22Usami+M%22">Usami M</searchLink>; Department of Pediatrics School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Takaki+Y%22">Takaki Y</searchLink>; Department of Pediatric Gastroenterology and Hepatology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ebana+R%22">Ebana R</searchLink>; Department of Pediatrics, Okinawa Chubu Hospital, Okinawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kurasawa+S%22">Kurasawa S</searchLink>; Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.<br /><searchLink fieldCode="AU" term="%22Fujikawa+H%22">Fujikawa H</searchLink>; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Ishige+T%22">Ishige T</searchLink>; Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan.<br /><searchLink fieldCode="AU" term="%22Kudo+T%22">Kudo T</searchLink>; Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+MM%22">Yoshida MM</searchLink>; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-Ku, Saitama, 3308777, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+H%22">Shimizu H</searchLink>; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Arai+K%22">Arai K</searchLink>; Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%229430794%22">Journal of gastroenterology</searchLink> [J Gastroenterol] 2026 Apr; Vol. 61 (4), pp. 398-409. <i>Date of Electronic Publication: </i>2026 Jan 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>9430794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-5922 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209441174%22">09441174 </searchLink><i>NLM ISO Abbreviation: </i>J Gastroenterol <i>Subsets: </i>MEDLINE
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