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Discovery, preclinical safety, and efficacy characterization of SMAC mimetic S-016-1348 as a potential cancer therapeutic.

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Title: Discovery, preclinical safety, and efficacy characterization of SMAC mimetic S-016-1348 as a potential cancer therapeutic.
Authors: Sinha A; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Nengroo MA; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Ali R; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Khan AA; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Dutta HS; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Singh A; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Saini KK; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Tripathi K; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Katekar R; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India., Rathaur S; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India., Vaishnav J; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India., Singh G; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India., Afsar M; Biochemistry and Structural Biology Division, CDRI, Lucknow 226031, India., Meena S; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Sahu A; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India., Shaw AK; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Singh K; Department of Endocrine Surgery, King George's Medical University, Lucknow, Uttar Pradesh 226003, India., Ramachandran R; Biochemistry and Structural Biology Division, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Chourasia MK; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Barthwal M; Pharmacology Division, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Yadav PN; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Kshatri AS; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Rangarajan R; Division of Molecular Microbiology and Immunology, CDRI, Lucknow 226031, India., Nazir A; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Ampapathi RS; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Gayen JR; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Koley D; Medicinal Process Chemistry, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Haq W; Medicinal Process Chemistry, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Datta D; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India. Electronic address: dipak.datta@cdri.res.in.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Apr 01; Vol. 34 (4), pp. 2408-2426. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2025.12.056