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Discovery, preclinical safety, and efficacy characterization of SMAC mimetic S-016-1348 as a potential cancer therapeutic.

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Title: Discovery, preclinical safety, and efficacy characterization of SMAC mimetic S-016-1348 as a potential cancer therapeutic.
Authors: Sinha A; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Nengroo MA; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Ali R; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Khan AA; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Dutta HS; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Singh A; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Saini KK; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Tripathi K; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Katekar R; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India., Rathaur S; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India., Vaishnav J; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India., Singh G; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India., Afsar M; Biochemistry and Structural Biology Division, CDRI, Lucknow 226031, India., Meena S; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India., Sahu A; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India., Shaw AK; Medicinal Process Chemistry, CDRI, Lucknow 226031, India., Singh K; Department of Endocrine Surgery, King George's Medical University, Lucknow, Uttar Pradesh 226003, India., Ramachandran R; Biochemistry and Structural Biology Division, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Chourasia MK; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Barthwal M; Pharmacology Division, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Yadav PN; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Kshatri AS; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Rangarajan R; Division of Molecular Microbiology and Immunology, CDRI, Lucknow 226031, India., Nazir A; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Ampapathi RS; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Gayen JR; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Koley D; Medicinal Process Chemistry, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Haq W; Medicinal Process Chemistry, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India., Datta D; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India. Electronic address: dipak.datta@cdri.res.in.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Apr 01; Vol. 34 (4), pp. 2408-2426. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
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  Data: Discovery, preclinical safety, and efficacy characterization of SMAC mimetic S-016-1348 as a potential cancer therapeutic.
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  Data: <searchLink fieldCode="AU" term="%22Sinha+A%22">Sinha A</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Nengroo+MA%22">Nengroo MA</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Ali+R%22">Ali R</searchLink>; Medicinal Process Chemistry, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Khan+AA%22">Khan AA</searchLink>; Medicinal Process Chemistry, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Dutta+HS%22">Dutta HS</searchLink>; Medicinal Process Chemistry, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Singh+A%22">Singh A</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Saini+KK%22">Saini KK</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Tripathi+K%22">Tripathi K</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Katekar+R%22">Katekar R</searchLink>; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Rathaur+S%22">Rathaur S</searchLink>; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Vaishnav+J%22">Vaishnav J</searchLink>; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Singh+G%22">Singh G</searchLink>; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Afsar+M%22">Afsar M</searchLink>; Biochemistry and Structural Biology Division, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Meena+S%22">Meena S</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Sahu+A%22">Sahu A</searchLink>; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Shaw+AK%22">Shaw AK</searchLink>; Medicinal Process Chemistry, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Department of Endocrine Surgery, King George's Medical University, Lucknow, Uttar Pradesh 226003, India.<br /><searchLink fieldCode="AU" term="%22Ramachandran+R%22">Ramachandran R</searchLink>; Biochemistry and Structural Biology Division, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Chourasia+MK%22">Chourasia MK</searchLink>; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Barthwal+M%22">Barthwal M</searchLink>; Pharmacology Division, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Yadav+PN%22">Yadav PN</searchLink>; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Kshatri+AS%22">Kshatri AS</searchLink>; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Rangarajan+R%22">Rangarajan R</searchLink>; Division of Molecular Microbiology and Immunology, CDRI, Lucknow 226031, India.<br /><searchLink fieldCode="AU" term="%22Nazir+A%22">Nazir A</searchLink>; Division of Neuroscience and Ageing Biology, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Ampapathi+RS%22">Ampapathi RS</searchLink>; Sophisticated Analytical Instrument Facility & Research, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Gayen+JR%22">Gayen JR</searchLink>; Pharmaceutics & Pharmacokinetics, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Koley+D%22">Koley D</searchLink>; Medicinal Process Chemistry, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Haq+W%22">Haq W</searchLink>; Medicinal Process Chemistry, CDRI, Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India.<br /><searchLink fieldCode="AU" term="%22Datta+D%22">Datta D</searchLink>; Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India. Electronic address: dipak.datta@cdri.res.in.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Apr 01; Vol. 34 (4), pp. 2408-2426. <i>Date of Electronic Publication: </i>2026 Jan 02.
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