Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages.

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Title: Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages.
Authors: Li YP; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital), Dongguan, China.; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China., Niu XJ; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China., Zhang G; Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou, China., Chan OK; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China., Sun N; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China., Hu B; Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou, China., Shi ZJ; Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China., Ouyang DY; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital), Dongguan, China.; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China., He XH; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China.; Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China., Zha QB; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital), Dongguan, China.; Center of Reproductive Medicine, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Source: Frontiers in immunology [Front Immunol] 2025 Dec 19; Vol. 16, pp. 1726408. Date of Electronic Publication: 2025 Dec 19 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2025.1726408