A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation.

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Bibliographic Details
Title: A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation.
Authors: Lacombe J; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; Department of Basic Medical Sciences, College of Medicine Phoenix, University of Arizona, 425 N 5th St., Phoenix, AZ 85004, USA., Dunn SE; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Layac M; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland., Soldevila M; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Fakrudin NM; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Duane B; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Chen K; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Barrett MW; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Helton J; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Laiakis EC; Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Center for Metabolomic Studies, Georgetown University, Washington DC 20057, USA., Fornace AJ Jr; Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Center for Metabolomic Studies, Georgetown University, Washington DC 20057, USA., Jani S; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA., Sorensen S; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA., Funaki S; Mitsubishi Gas Chemical Company, Inc., Tokyo, Japan., Diaz A; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA., Zenhausern F; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; Department of Basic Medical Sciences, College of Medicine Phoenix, University of Arizona, 425 N 5th St., Phoenix, AZ 85004, USA.; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Department of Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721, USA.; HonorHealth Research Institute, Scottsdale, AZ 85258, USA.
Source: IScience [iScience] 2025 Nov 26; Vol. 29 (1), pp. 114236. Date of Electronic Publication: 2025 Nov 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.114236