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A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation.

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Title: A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation.
Authors: Lacombe J; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; Department of Basic Medical Sciences, College of Medicine Phoenix, University of Arizona, 425 N 5th St., Phoenix, AZ 85004, USA., Dunn SE; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Layac M; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland., Soldevila M; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Fakrudin NM; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Duane B; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Chen K; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Barrett MW; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Helton J; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA., Laiakis EC; Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Center for Metabolomic Studies, Georgetown University, Washington DC 20057, USA., Fornace AJ Jr; Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Center for Metabolomic Studies, Georgetown University, Washington DC 20057, USA., Jani S; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA., Sorensen S; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA., Funaki S; Mitsubishi Gas Chemical Company, Inc., Tokyo, Japan., Diaz A; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA., Zenhausern F; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; Department of Basic Medical Sciences, College of Medicine Phoenix, University of Arizona, 425 N 5th St., Phoenix, AZ 85004, USA.; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Department of Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721, USA.; HonorHealth Research Institute, Scottsdale, AZ 85258, USA.
Source: IScience [iScience] 2025 Nov 26; Vol. 29 (1), pp. 114236. Date of Electronic Publication: 2025 Nov 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation.
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  Data: <searchLink fieldCode="AU" term="%22Lacombe+J%22">Lacombe J</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; Department of Basic Medical Sciences, College of Medicine Phoenix, University of Arizona, 425 N 5th St., Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+SE%22">Dunn SE</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Layac+M%22">Layac M</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Soldevila+M%22">Soldevila M</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Fakrudin+NM%22">Fakrudin NM</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Duane+B%22">Duane B</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+MW%22">Barrett MW</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Helton+J%22">Helton J</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Laiakis+EC%22">Laiakis EC</searchLink>; Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Center for Metabolomic Studies, Georgetown University, Washington DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Fornace+AJ+Jr%22">Fornace AJ Jr</searchLink>; Department of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.; Center for Metabolomic Studies, Georgetown University, Washington DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Jani+S%22">Jani S</searchLink>; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Sorensen+S%22">Sorensen S</searchLink>; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Funaki+S%22">Funaki S</searchLink>; Mitsubishi Gas Chemical Company, Inc., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Diaz+A%22">Diaz A</searchLink>; Dignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA.<br /><searchLink fieldCode="AU" term="%22Zenhausern+F%22">Zenhausern F</searchLink>; Center for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.; Department of Basic Medical Sciences, College of Medicine Phoenix, University of Arizona, 425 N 5th St., Phoenix, AZ 85004, USA.; School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Department of Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721, USA.; HonorHealth Research Institute, Scottsdale, AZ 85258, USA.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Nov 26; Vol. 29 (1), pp. 114236. <i>Date of Electronic Publication: </i>2025 Nov 26 (<i>Print Publication: </i>2026).
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