The effect of obesity and aging on NAD+/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI.

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Title: The effect of obesity and aging on NAD+/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI.
Authors: Lapatto HAK; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. helena.lapatto@helsinki.fi., van der Kolk BW; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Muniandy M; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Heinonen S; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Internal Medicine and Rehabilitation, Helsinki University Hospital, Helsinki, Finland., Heikkinen A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Alvarez M; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Lee SHT; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Jokinen R; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lundbom J; Department of Radiology, Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Kuula J; Department of Radiology, Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland., Hakkarainen A; Department of Radiology, Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Groop PH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Tukiainen T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Ollikainen M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Pirinen E; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland., Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. kirsi.pietilainen@helsinki.fi.; HealthyWeightHub, Abdominal Center, Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. kirsi.pietilainen@helsinki.fi.
Source: International journal of obesity (2005) [Int J Obes (Lond)] 2026 Apr; Vol. 50 (4), pp. 797-805. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article; Twin Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101256108 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5497 (Electronic) Linking ISSN: 03070565 NLM ISO Abbreviation: Int J Obes (Lond) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5497
DOI:10.1038/s41366-025-02007-w