OMG! A proteomic determinant of neurodegenerative resiliency.

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Title: OMG! A proteomic determinant of neurodegenerative resiliency.
Authors: Duggan MR; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Oh HS; Graduate Program in Stem Cell and Regenerative Medicine, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Frank P; Department of Epidemiology and Public Health, University College London, London, UK.; Brain Sciences, University College London, London, UK., Gomez GT; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Zweibaum D; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Cui Y; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, Philadelphia, PA, USA., Chen J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Surapaneni A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA., Blew CO; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Dark HE; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Joynes CM; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Kandala S; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Bilgel M; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Farinas A; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Erus G; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, Philadelphia, PA, USA., Tian Q; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Candia J; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Pucha KA; Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Landman BA; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Dumitrescu L; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Lewis A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moghekar A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Siavoshi F; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ali M; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA., Liu M; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA., Xu Y; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA., Western D; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA., Kaneko N; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan., Kato S; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; Foneslife Corporation, Chuo-ku, Tokyo, Japan., Furuichi M; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; Foneslife Corporation, Chuo-ku, Tokyo, Japan., Shibayama M; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; Foneslife Corporation, Chuo-ku, Tokyo, Japan., Katsuno M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan., Nishita Y; Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan., Otsuka R; Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan., Gottesman RF; Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Dammer EB; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.; Goizueta Brain Health Institute and Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Neurodegenerative Disease Center, Emory University School of Medicine, Atlanta, Georgia, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.; Goizueta Brain Health Institute and Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Neurodegenerative Disease Center, Emory University School of Medicine, Atlanta, Georgia, USA., Levey AI; Goizueta Brain Health Institute and Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Neurodegenerative Disease Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA., B Johnson EC; Goizueta Brain Health Institute and Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Neurodegenerative Disease Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia, USA., Mormino E; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Wagner AD; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Psychology, Stanford University, Stanford, CA, USA., Poston KL; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Kapogiannis D; Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Grams ME; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA., Bhargava P; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Waga I; NEC Solution Innovators Limited, Koto-ku, Tokyo, Japan.; Foneslife Corporation, Chuo-ku, Tokyo, Japan.; Tohoku University, Aoba-ku, Sendai, Japan., Davatzikos C; Artificial Intelligence in Biomedical Imaging Laboratory, Perelman School of Medicine, Philadelphia, PA, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Wyss-Coray T; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Kivimäki M; Brain Sciences, University College London, London, UK.; University of Helsinki, Helsinki, Finland., Coresh J; Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA., Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH BRC BG RM 04B311, 251 Bayview Blvd, Baltimore, MD, 21224, USA. keenan.walker@nih.gov.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 Jan 05; Vol. 21 (1), pp. 9. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1750-1326
DOI:10.1186/s13024-025-00921-1