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Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial.

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Title: Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial.
Authors: Kapulu MC; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya. mkapulu@kemri-wellcome.org.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK. mkapulu@kemri-wellcome.org., Orenge F; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Kimani D; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Kibwana E; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Kibet H; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mutahi M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Datoo MS; Jenner Institute, University of Oxford, Oxford, UK., Bellamy D; Jenner Institute, University of Oxford, Oxford, UK., Musembi J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Ngoto O; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Rashid H; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Akinyi S; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mwatasa MH; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Nyamako L; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Keter K; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Gatheru R; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mutiso A; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Musyoki J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mwacharo J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Abebe Y; Sanaria Inc., Rockville, MD, USA., James ER; Sanaria Inc., Rockville, MD, USA., Billingsley PF; Sanaria Inc., Rockville, MD, USA., Ngetsa C; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mosobo M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Makale J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Tawa B; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Wamae K; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Ochola-Oyier LI; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Lawrie A; Jenner Institute, University of Oxford, Oxford, UK., Ramos-Lopez F; Jenner Institute, University of Oxford, Oxford, UK., Roberts R; Jenner Institute, University of Oxford, Oxford, UK., Richie TL; Sanaria Inc., Rockville, MD, USA., Sim BKL; Sanaria Inc., Rockville, MD, USA., Hoffman SL; Sanaria Inc., Rockville, MD, USA., Ewer KJ; Jenner Institute, University of Oxford, Oxford, UK., Hill AVS; Jenner Institute, University of Oxford, Oxford, UK., Hamaluba M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK., Bejon P; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK.; Department of Modernising Medical Microbiology, Nuffield Department of Medicine, University Oxford, Oxford, UK.
Source: Nature medicine [Nat Med] 2026 Jan; Vol. 32 (1), pp. 178-185. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-025-04107-6