Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial.
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| Title: | Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial. |
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| Authors: | Kapulu MC; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya. mkapulu@kemri-wellcome.org.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK. mkapulu@kemri-wellcome.org., Orenge F; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Kimani D; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Kibwana E; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Kibet H; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mutahi M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Datoo MS; Jenner Institute, University of Oxford, Oxford, UK., Bellamy D; Jenner Institute, University of Oxford, Oxford, UK., Musembi J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Ngoto O; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Rashid H; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Akinyi S; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mwatasa MH; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Nyamako L; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Keter K; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Gatheru R; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mutiso A; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Musyoki J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mwacharo J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Abebe Y; Sanaria Inc., Rockville, MD, USA., James ER; Sanaria Inc., Rockville, MD, USA., Billingsley PF; Sanaria Inc., Rockville, MD, USA., Ngetsa C; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Mosobo M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Makale J; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Tawa B; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Wamae K; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Ochola-Oyier LI; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya., Lawrie A; Jenner Institute, University of Oxford, Oxford, UK., Ramos-Lopez F; Jenner Institute, University of Oxford, Oxford, UK., Roberts R; Jenner Institute, University of Oxford, Oxford, UK., Richie TL; Sanaria Inc., Rockville, MD, USA., Sim BKL; Sanaria Inc., Rockville, MD, USA., Hoffman SL; Sanaria Inc., Rockville, MD, USA., Ewer KJ; Jenner Institute, University of Oxford, Oxford, UK., Hill AVS; Jenner Institute, University of Oxford, Oxford, UK., Hamaluba M; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK., Bejon P; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK.; Department of Modernising Medical Microbiology, Nuffield Department of Medicine, University Oxford, Oxford, UK. |
| Source: | Nature medicine [Nat Med] 2026 Jan; Vol. 32 (1), pp. 178-185. Date of Electronic Publication: 2026 Jan 06. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41495411 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kapulu+MC%22">Kapulu MC</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya. mkapulu@kemri-wellcome.org.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK. mkapulu@kemri-wellcome.org.<br /><searchLink fieldCode="AU" term="%22Orenge+F%22">Orenge F</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Kimani+D%22">Kimani D</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Kibwana+E%22">Kibwana E</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Kibet+H%22">Kibet H</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mutahi+M%22">Mutahi M</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Datoo+MS%22">Datoo MS</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bellamy+D%22">Bellamy D</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Musembi+J%22">Musembi J</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Ngoto+O%22">Ngoto O</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Rashid+H%22">Rashid H</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Akinyi+S%22">Akinyi S</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mwatasa+MH%22">Mwatasa MH</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Nyamako+L%22">Nyamako L</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Keter+K%22">Keter K</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Gatheru+R%22">Gatheru R</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mutiso+A%22">Mutiso A</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Musyoki+J%22">Musyoki J</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mwacharo+J%22">Mwacharo J</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Abebe+Y%22">Abebe Y</searchLink>; Sanaria Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22James+ER%22">James ER</searchLink>; Sanaria Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Billingsley+PF%22">Billingsley PF</searchLink>; Sanaria Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ngetsa+C%22">Ngetsa C</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mosobo+M%22">Mosobo M</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Makale+J%22">Makale J</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Tawa+B%22">Tawa B</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Wamae+K%22">Wamae K</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Ochola-Oyier+LI%22">Ochola-Oyier LI</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ramos-Lopez+F%22">Ramos-Lopez F</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Richie+TL%22">Richie TL</searchLink>; Sanaria Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sim+BKL%22">Sim BKL</searchLink>; Sanaria Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+SL%22">Hoffman SL</searchLink>; Sanaria Inc., Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hamaluba+M%22">Hamaluba M</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bejon+P%22">Bejon P</searchLink>; Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Welcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University Oxford, Oxford, UK.; Department of Modernising Medical Microbiology, Nuffield Department of Medicine, University Oxford, Oxford, UK. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Jan; Vol. 32 (1), pp. 178-185. <i>Date of Electronic Publication: </i>2026 Jan 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE |
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