Noninvasive in vivo deoxycytidine kinase (dCK)-PET identifies tumor-draining lymph nodes upon immune checkpoint inhibitor therapy.

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Title: Noninvasive in vivo deoxycytidine kinase (dCK)-PET identifies tumor-draining lymph nodes upon immune checkpoint inhibitor therapy.
Authors: Philippe C; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany., Cotton J; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany., Bowden GD; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany., Pöschel S; Core Facility Flow Cytometry of the Medical Faculty Tübingen, Eberhard Karls University, Tuebingen, Germany., Knopf P; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany., Schörg B; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany., Gonzalez-Menendez I; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany.; Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tuebingen, Eberhard Karls University, Tübingen, Germany., Sonanini D; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany.; Department of Medical Oncology and Pneumology, Eberhard Karls University, Tuebingen, Germany., Flatz L; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany.; Department of Dermatology, Eberhard Karls University, Tuebingen, Germany., Allen-Auerbach M; Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA., Radu CG; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA., Czernin J; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA., Quintanilla-Martinez L; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany.; Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tuebingen, Eberhard Karls University, Tübingen, Germany., Hacker M; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria., Pichler BJ; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany., Maurer A; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany., Kneilling M; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tuebingen, Germany. manfred.kneilling@med.uni-tuebingen.de.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University, Tuebingen, Germany. manfred.kneilling@med.uni-tuebingen.de.; Department of Dermatology, Eberhard Karls University, Tuebingen, Germany. manfred.kneilling@med.uni-tuebingen.de.
Source: Npj imaging [Npj Imaging] 2026 Jan 06; Vol. 4 (1), pp. 1. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 9918733285306676 Publication Model: Electronic Cited Medium: Internet ISSN: 2948-197X (Electronic) Linking ISSN: 2948197X NLM ISO Abbreviation: Npj Imaging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2948-197X
DOI:10.1038/s44303-025-00133-8