Distribution and prognostic significance of myelotoxicity in newly diagnosed glioblastoma in a real-life cohort: Time to treat more aggressively?

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Title: Distribution and prognostic significance of myelotoxicity in newly diagnosed glioblastoma in a real-life cohort: Time to treat more aggressively?
Authors: Oster C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.).; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany., Reineck P; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Schmidt T; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Grieger J; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Sharma S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Feldheim J; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.).; Department of Neurology, University Hospital Nuernberg, Paracelsus Medical University, Nuernberg, Germany., Kizina K; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Cappello G; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Jekel L; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Pabst KM; Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany ; National Centre for Tumor Diseases (NCT), NCT West, Germany., Ahmadipour Y; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Karadachi H; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Rauschenbach L; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Lazaridis L; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Guberina N; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Pöttgen C; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Blau T; Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Keyvani K; Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Scheffler B; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany., Herrmann K; Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany ; National Centre for Tumor Diseases (NCT), NCT West, Germany., Kleinschnitz C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.)., Sure U; Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Stuschke M; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Glas M; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.).; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology, St Marien Hospital, Lünen, Germany.; Department of Neurooncology, Center for Neurology, University Hospital Bonn, Bonn, Germany., Kebir S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany (C.O., P.R., T.S., J.G., S.S., J.F., K.K., G.C., L.J. C.K., M.G., S.K.).; German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, Germany, DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany ; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Source: Neuro-oncology advances [Neurooncol Adv] 2025 Dec 05; Vol. 7 (1), pp. vdaf218. Date of Electronic Publication: 2025 Dec 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755003 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-2498 (Electronic) Linking ISSN: 26322498 NLM ISO Abbreviation: Neurooncol Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2632-2498
DOI:10.1093/noajnl/vdaf218