Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse.
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| Title: | Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse. |
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| Authors: | Kang Y; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China., Li M; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.; Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, No. 42, Zhaowuda Road, Hohhot, Inner Mongolia, 010020, P.R. China., Hu B; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.; Department of Spine Surgery, Tongliao People's Hospital, Tongliao, 028000, Inner Mongolia, P.R. China., Lv Y; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China., Du J; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China., Zhang D; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China. 462570672@qq.com., Zhou H; Department of Spine Surgery, Tongliao People's Hospital, Tongliao, 028000, Inner Mongolia, P.R. China. zhouhengxing@sdu.edu.cn.; Department of Orthopaedics, Cheeloo College of Medicine, Shandong University Centre for Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, P.R. China. zhouhengxing@sdu.edu.cn., Feng S; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China. shiqingfeng@sdu.edu.cn.; Department of Orthopaedics, Cheeloo College of Medicine, Shandong University Centre for Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, P.R. China. shiqingfeng@sdu.edu.cn. |
| Source: | Inflammation [Inflammation] 2026 Jan 07; Vol. 49 (1), pp. 34. Date of Electronic Publication: 2026 Jan 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1573-2576 |
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| DOI: | 10.1007/s10753-025-02429-8 |
