Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse.
Saved in:
| Title: | Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse. |
|---|---|
| Authors: | Kang Y; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China., Li M; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.; Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, No. 42, Zhaowuda Road, Hohhot, Inner Mongolia, 010020, P.R. China., Hu B; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.; Department of Spine Surgery, Tongliao People's Hospital, Tongliao, 028000, Inner Mongolia, P.R. China., Lv Y; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China., Du J; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China., Zhang D; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China. 462570672@qq.com., Zhou H; Department of Spine Surgery, Tongliao People's Hospital, Tongliao, 028000, Inner Mongolia, P.R. China. zhouhengxing@sdu.edu.cn.; Department of Orthopaedics, Cheeloo College of Medicine, Shandong University Centre for Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, P.R. China. zhouhengxing@sdu.edu.cn., Feng S; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China. shiqingfeng@sdu.edu.cn.; Department of Orthopaedics, Cheeloo College of Medicine, Shandong University Centre for Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, P.R. China. shiqingfeng@sdu.edu.cn. |
| Source: | Inflammation [Inflammation] 2026 Jan 07; Vol. 49 (1), pp. 34. Date of Electronic Publication: 2026 Jan 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41501191 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.; Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, No. 42, Zhaowuda Road, Hohhot, Inner Mongolia, 010020, P.R. China.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.; Department of Spine Surgery, Tongliao People's Hospital, Tongliao, 028000, Inner Mongolia, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lv+Y%22">Lv Y</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.<br /><searchLink fieldCode="AU" term="%22Du+J%22">Du J</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China. 462570672@qq.com.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Spine Surgery, Tongliao People's Hospital, Tongliao, 028000, Inner Mongolia, P.R. China. zhouhengxing@sdu.edu.cn.; Department of Orthopaedics, Cheeloo College of Medicine, Shandong University Centre for Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, P.R. China. zhouhengxing@sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Feng+S%22">Feng S</searchLink>; Department of Orthopaedics, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, 154 Anshan Road, Heping District, Tianjin, 300052, P.R. China. shiqingfeng@sdu.edu.cn.; Department of Orthopaedics, Cheeloo College of Medicine, Shandong University Centre for Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, P.R. China. shiqingfeng@sdu.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227600105%22">Inflammation</searchLink> [Inflammation] 2026 Jan 07; Vol. 49 (1), pp. 34. <i>Date of Electronic Publication: </i>2026 Jan 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic%2FPlenum+Publishers%22">Kluwer Academic/Plenum Publishers </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7600105 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-2576 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203603997%22">03603997 </searchLink><i>NLM ISO Abbreviation: </i>Inflammation <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41501191 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10753-025-02429-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 34 Titles: – TitleFull: Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kang Y – PersonEntity: Name: NameFull: Li M – PersonEntity: Name: NameFull: Hu B – PersonEntity: Name: NameFull: Lv Y – PersonEntity: Name: NameFull: Du J – PersonEntity: Name: NameFull: Zhang D – PersonEntity: Name: NameFull: Zhou H – PersonEntity: Name: NameFull: Feng S IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 01 Text: 2026 Jan 07 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1573-2576 Numbering: – Type: volume Value: 49 – Type: issue Value: 1 Titles: – TitleFull: Inflammation Type: main |
| ResultId | 1 |
