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Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway.

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Title: Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway.
Authors: Wang XY; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China.; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Zhou WS; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China., Gaur U; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China., Zhen XC; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. zhenxuechu@suda.edu.cn., Zheng WH; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China. wenhuazheng@um.edu.mo.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Apr; Vol. 47 (4), pp. 888-902. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway.
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  Data: <searchLink fieldCode="AU" term="%22Wang+XY%22">Wang XY</searchLink>; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China.; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Zhou+WS%22">Zhou WS</searchLink>; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China.<br /><searchLink fieldCode="AU" term="%22Gaur+U%22">Gaur U</searchLink>; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China.<br /><searchLink fieldCode="AU" term="%22Zhen+XC%22">Zhen XC</searchLink>; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. zhenxuechu@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+WH%22">Zheng WH</searchLink>; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China. wenhuazheng@um.edu.mo.
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        Value: 10.1038/s41401-025-01703-7
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              Text: 2026 Apr
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