Voxelwise correlation of neighbors as a hypothesis driven framework for characterizing white matter lesion heterogeneity.

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Title: Voxelwise correlation of neighbors as a hypothesis driven framework for characterizing white matter lesion heterogeneity.
Authors: Alshikho MJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Lao PJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Edwards NC; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Pyne JD; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Cotton-Samuel D; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Morales CD; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Berroa J; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Morel N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Benavides A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Ventura RE; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Lippert RV; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Hale C; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA., Manly JJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mayeux RP; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA. amb2139@columbia.edu.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. amb2139@columbia.edu.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. amb2139@columbia.edu.
Source: Scientific reports [Sci Rep] 2026 Jan 08; Vol. 16 (1), pp. 3427. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Voxelwise correlation of neighbors as a hypothesis driven framework for characterizing white matter lesion heterogeneity.
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  Data: <searchLink fieldCode="AU" term="%22Alshikho+MJ%22">Alshikho MJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lao+PJ%22">Lao PJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+NC%22">Edwards NC</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. 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Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cotton-Samuel+D%22">Cotton-Samuel D</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Morales+CD%22">Morales CD</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Berroa+J%22">Berroa J</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Morel+N%22">Morel N</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Benavides+A%22">Benavides A</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Ventura+RE%22">Ventura RE</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Lippert+RV%22">Lippert RV</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Hale+C%22">Hale C</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Manly+JJ%22">Manly JJ</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mayeux+RP%22">Mayeux RP</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA. amb2139@columbia.edu.; Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. amb2139@columbia.edu.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. amb2139@columbia.edu.
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