Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.

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Title: Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.
Authors: Cosgun KN; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Jumaa H; Signalling Research Centres BIOSS and CIBSS, Albert Ludwigs University of Freiburg, Freiburg, Germany., Robinson ME; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Cheng Z; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.; Department of Immunobiology, Yale University, New Haven, CT, USA., Oulghazi S; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Kume K; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Fonseca Arce D; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Agadzhanian N; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Kistner KM; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Leveille E; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Drivet E; Department of Immunology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B-Cell Malignancies, Oslo University, Oslo, Norway., Yu F; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA., Qian Z; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA., Song JY; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chan WC; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Xu L; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.; College of Life Sciences and School of Medicine, Zhejiang University, Hangzhou, China., Xiao G; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.; College of Life Sciences and School of Medicine, Zhejiang University, Hangzhou, China., Taketo MM; Kyoto University Yoshida-Honmachi Sakyo, Kyoto, Japan., Kothari S; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Schjerven H; Department of Immunology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B-Cell Malignancies, Oslo University, Oslo, Norway.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Jellusova J; Signalling Research Centres BIOSS and CIBSS, Albert Ludwigs University of Freiburg, Freiburg, Germany.; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Müschen M; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA. markus.muschen@yale.edu.; Department of Immunobiology, Yale University, New Haven, CT, USA. markus.muschen@yale.edu.
Source: Nature cancer [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 150-168. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-1347
DOI:10.1038/s43018-025-01093-z