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Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.

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Title: Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.
Authors: Cosgun KN; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Jumaa H; Signalling Research Centres BIOSS and CIBSS, Albert Ludwigs University of Freiburg, Freiburg, Germany., Robinson ME; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Cheng Z; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.; Department of Immunobiology, Yale University, New Haven, CT, USA., Oulghazi S; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Kume K; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Fonseca Arce D; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Agadzhanian N; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Kistner KM; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Leveille E; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Drivet E; Department of Immunology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B-Cell Malignancies, Oslo University, Oslo, Norway., Yu F; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA., Qian Z; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA., Song JY; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chan WC; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Xu L; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.; College of Life Sciences and School of Medicine, Zhejiang University, Hangzhou, China., Xiao G; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.; College of Life Sciences and School of Medicine, Zhejiang University, Hangzhou, China., Taketo MM; Kyoto University Yoshida-Honmachi Sakyo, Kyoto, Japan., Kothari S; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA., Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Schjerven H; Department of Immunology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B-Cell Malignancies, Oslo University, Oslo, Norway.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Jellusova J; Signalling Research Centres BIOSS and CIBSS, Albert Ludwigs University of Freiburg, Freiburg, Germany.; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany., Müschen M; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA. markus.muschen@yale.edu.; Department of Immunobiology, Yale University, New Haven, CT, USA. markus.muschen@yale.edu.
Source: Nature cancer [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 150-168. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Cosgun+KN%22">Cosgun KN</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Jumaa+H%22">Jumaa H</searchLink>; Signalling Research Centres BIOSS and CIBSS, Albert Ludwigs University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Robinson+ME%22">Robinson ME</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.; Department of Immunobiology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Oulghazi+S%22">Oulghazi S</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kume+K%22">Kume K</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Fonseca+Arce+D%22">Fonseca Arce D</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Agadzhanian+N%22">Agadzhanian N</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kistner+KM%22">Kistner KM</searchLink>; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Leveille+E%22">Leveille E</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Drivet+E%22">Drivet E</searchLink>; Department of Immunology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B-Cell Malignancies, Oslo University, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Yu+F%22">Yu F</searchLink>; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.<br /><searchLink fieldCode="AU" term="%22Qian+Z%22">Qian Z</searchLink>; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.<br /><searchLink fieldCode="AU" term="%22Song+JY%22">Song JY</searchLink>; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chan+WC%22">Chan WC</searchLink>; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.; College of Life Sciences and School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xiao+G%22">Xiao G</searchLink>; Department of Systems Biology, City of Hope Comprehensive Cancer Center Biomedical Research Center, Monrovia, CA, USA.; College of Life Sciences and School of Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Taketo+MM%22">Taketo MM</searchLink>; Kyoto University Yoshida-Honmachi Sakyo, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kothari+S%22">Kothari S</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Davids+MS%22">Davids MS</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schjerven+H%22">Schjerven H</searchLink>; Department of Immunology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B-Cell Malignancies, Oslo University, Oslo, Norway.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jellusova+J%22">Jellusova J</searchLink>; Signalling Research Centres BIOSS and CIBSS, Albert Ludwigs University of Freiburg, Freiburg, Germany.; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müschen+M%22">Müschen M</searchLink>; Center of Molecular and Cellular Oncology, Yale University, New Haven, CT, USA. markus.muschen@yale.edu.; Department of Immunobiology, Yale University, New Haven, CT, USA. markus.muschen@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 150-168. <i>Date of Electronic Publication: </i>2026 Jan 08.
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