Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease.

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Title: Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease.
Authors: Ueda J; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Uemura N; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Neurological Disease Control, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.; Department of therapeutics for Multiple System Atrophy, Kyoto University Graduate School of Medicine, Kyoto, Japan., Chang J; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hirato T; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ishimoto T; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Oono M; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsuzawa S; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of therapeutics for Multiple System Atrophy, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsumoto R; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yamakado H; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of therapeutics for Multiple System Atrophy, Kyoto University Graduate School of Medicine, Kyoto, Japan., Takahashi R; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of therapeutics for Multiple System Atrophy, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Source: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2026 May; Vol. 41 (5), pp. 1183-1196. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1531-8257
DOI:10.1002/mds.70191