PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation.

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Title: PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation.
Authors: Butic AB; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Afanasiev E; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Spencer SA; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Abdelmageed M; Department of Neuroscience and Experimental Therapeutics, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Paul A; Department of Neuroscience and Experimental Therapeutics, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Alexander KM; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Ayers KN; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Schell TD; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Lauver MD; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Jin G; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Borys SM; Division of Biology and Medicine, Department of Molecular Microbiology & Immunology, Brown University, Providence, RI, 02906, USA., Brossay L; Division of Biology and Medicine, Department of Molecular Microbiology & Immunology, Brown University, Providence, RI, 02906, USA., Stratton JAA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Walter V; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Lukacher AE; Department of Cell and Biological Systems, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Source: Research square [Res Sq] 2025 Dec 12. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-8215051/v1