M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

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Title: M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.
Authors: Komiyama S; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.; Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo 108-8345, Japan., Kodaira Y; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Maeda R; Multi-Omics Platform, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Sugiura Y; Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo 108-8345, Japan.; Multi-Omics Platform, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.; Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan., Suzuki K; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Saeki A; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Kinashi Y; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Oguchi H; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Takano K; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Onawa S; Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, Kawasaki 210-0821, Japan., Matsui A; Division of Allergy and Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 811-1347, Japan., Sasaki E; Division of Analytical Chemistry for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Hattori-Muroi K; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Kimura S; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Fujimura Y; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Ka Y; Humanized Model Laboratory, Animal Resource Technical Research Center, Central Institute for Experimental Medicine and Life Science, Kanagawa 210-0821, Japan., Ogura T; Humanized Model Laboratory, Animal Resource Technical Research Center, Central Institute for Experimental Medicine and Life Science, Kanagawa 210-0821, Japan., Hanaoka K; Division of Analytical Chemistry for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Ito M; Division of Allergy and Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 811-1347, Japan., Watarai H; Department of Immunology and Stem Cell Biology, Kanazawa University, Kanazawa 920-8640, Japan., Kaisho T; Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama 641-8509, Japan., Udagawa N; Department of Biochemistry, Matsumoto Dental University, Shiojiri 399-0781, Japan., Takahashi D; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan., Hase K; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.; Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo 108-8345, Japan.; Research Management Division, The Institute of Fermentation Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima 960-1296, Japan.; Division of Mucosal Vaccine, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 13; Vol. 123 (2), pp. e2506550123. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2506550123