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Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats.

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Title: Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats.
Authors: Bella A; Physiology, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Centre for Pain Research, University of Galway, Galway, Ireland.; Centre National De la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France., Abdallah K; Centre National De la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France., Rodrigues-Amorim D; Physiology, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Centre for Pain Research, University of Galway, Galway, Ireland., Diego AM; Physiology, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Centre for Pain Research, University of Galway, Galway, Ireland.; Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Decraene C; Centre National De la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France., Hener P; Centre National De la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France., Di Marino C; Physiology, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.; Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Centre for Pain Research, University of Galway, Galway, Ireland.; Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Finn DP; Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Centre for Pain Research, University of Galway, Galway, Ireland.; Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Yalcin I; Centre National De la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France. yalcin@inci-cnrs.unistra.fr., Roche M; Physiology, School of Pharmacy and Medical Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland. michelle.roche@universityofgalway.ie.; Galway Neuroscience Centre, University of Galway, Galway, Ireland. michelle.roche@universityofgalway.ie.; Centre for Pain Research, University of Galway, Galway, Ireland. michelle.roche@universityofgalway.ie.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 May; Vol. 51 (6), pp. 1032-1044. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1740-634X
DOI:10.1038/s41386-025-02305-x