A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial.

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Title: A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial.
Authors: Fonteneau C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Tamayo Z; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Price A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Pan L; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Afriyie-Agyemang Y; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Agrawal S; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Butler A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Cail C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Calkins M; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Chakilam AR; AbbVie Inc., North Chicago IL, USA., Forselius-Bielen K; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Fram G; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Frazier A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Gil R; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Govil P; New York State Psychiatric Institute, New York NY, USA., Gray DL; Vigil Neuroscience, Watertown MA, USA., Grinband J; New York State Psychiatric Institute, New York NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA; Department of Radiology, Columbia University Irving Medical Center, New York NY, USA., Gur RC; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Haubold NK; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Heffernan Z; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Heneks M; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Kegeles L; New York State Psychiatric Institute, New York NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA., Kohler C; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Lin C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Lu J; Investigational Drug Service, Yale New Haven Hospital, New Haven CT, USA., Mayer M; New York State Psychiatric Institute, New York NY, USA., Pham P; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Perlman G; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Rahmati M; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Ranganathan M; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; VA Connecticut Healthcare System, West Haven CT, USA., Santamauro NP; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Schutte CW; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Selloni A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Van Snellenberg J; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Surti T; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; VA Connecticut Healthcare System, West Haven CT, USA., Wolf DH; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Zharyy C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Abi-Dargham A; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Gur RE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Lieberman JA; Columbia University, College of Physicians and Surgeons, New York NY, USA., Kantrowitz JT; New York State Psychiatric Institute, New York NY, USA; Columbia University, College of Physicians and Surgeons, New York NY, USA; Nathan Kline Institute, Orangeburg NY, USA., Anticevic A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Cho YT; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven CT, USA; Child Study Center, Yale University School of Medicine, New Haven CT, USA. Electronic address: youngsun.cho@yale.edu., Krystal JH; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.
Corporate Authors: TRANSCENDS Group; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA.
Source: Journal of psychiatric research [J Psychiatr Res] 2026 Mar; Vol. 194, pp. 196-210. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article; Randomized Controlled Trial; Review
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-1379
DOI:10.1016/j.jpsychires.2025.12.020