Toxicity and Treatment Completion of Neoadjuvant FOLFOXIRI and Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: A Secondary Outcome Analysis of the MEND-IT Trial.

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Title: Toxicity and Treatment Completion of Neoadjuvant FOLFOXIRI and Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: A Secondary Outcome Analysis of the MEND-IT Trial.
Authors: Banken E; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands. Electronic address: evi.banken@catharinaziekenhuis.nl., van den Berg K; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands., van Hellemond IEG; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Peulen HMU; Department of Radiotherapy, Catharina Hospital, Eindhoven, the Netherlands., Nederend J; Department of Radiology, Catharina Hospital, Eindhoven, the Netherlands., Steller EJA; Department of Surgery, Isala, Zwolle, the Netherlands., de Groot JWB; Department of Medical Oncology, Isala, Zwolle, the Netherlands., Verhoef C; Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands., Aalbers AGJ; Department of Surgery, Antoni van Leeuwenhoek, Amsterdam, the Netherlands., Vincent J; Department of Medical Oncology, Elkerliek Hospital, Helmond, the Netherlands., Buffart TE; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center, Amsterdam, the Netherlands., Werter IM; Department of Medical Oncology, Rijnstate, Arnhem, the Netherlands., Douma JAJ; Department of Medical Oncology, Frisius Medical Center, location Leeuwarden, Leeuwarden, the Netherlands., Bloemen JG; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands., Burger JWA; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands.
Source: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2026 Jul 15; Vol. 125 (4), pp. 1008-1017. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2025.12.052