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Toxicity and Treatment Completion of Neoadjuvant FOLFOXIRI and Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: A Secondary Outcome Analysis of the MEND-IT Trial.

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Title: Toxicity and Treatment Completion of Neoadjuvant FOLFOXIRI and Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: A Secondary Outcome Analysis of the MEND-IT Trial.
Authors: Banken E; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands. Electronic address: evi.banken@catharinaziekenhuis.nl., van den Berg K; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands., van Hellemond IEG; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Peulen HMU; Department of Radiotherapy, Catharina Hospital, Eindhoven, the Netherlands., Nederend J; Department of Radiology, Catharina Hospital, Eindhoven, the Netherlands., Steller EJA; Department of Surgery, Isala, Zwolle, the Netherlands., de Groot JWB; Department of Medical Oncology, Isala, Zwolle, the Netherlands., Verhoef C; Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands., Aalbers AGJ; Department of Surgery, Antoni van Leeuwenhoek, Amsterdam, the Netherlands., Vincent J; Department of Medical Oncology, Elkerliek Hospital, Helmond, the Netherlands., Buffart TE; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center, Amsterdam, the Netherlands., Werter IM; Department of Medical Oncology, Rijnstate, Arnhem, the Netherlands., Douma JAJ; Department of Medical Oncology, Frisius Medical Center, location Leeuwarden, Leeuwarden, the Netherlands., Bloemen JG; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands., Burger JWA; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands.
Source: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2026 Jul 15; Vol. 125 (4), pp. 1008-1017. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toxicity and Treatment Completion of Neoadjuvant FOLFOXIRI and Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: A Secondary Outcome Analysis of the MEND-IT Trial.
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  Data: <searchLink fieldCode="AU" term="%22Banken+E%22">Banken E</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands. Electronic address: evi.banken@catharinaziekenhuis.nl.<br /><searchLink fieldCode="AU" term="%22van+den+Berg+K%22">van den Berg K</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hellemond+IEG%22">van Hellemond IEG</searchLink>; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peulen+HMU%22">Peulen HMU</searchLink>; Department of Radiotherapy, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nederend+J%22">Nederend J</searchLink>; Department of Radiology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Steller+EJA%22">Steller EJA</searchLink>; Department of Surgery, Isala, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Groot+JWB%22">de Groot JWB</searchLink>; Department of Medical Oncology, Isala, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verhoef+C%22">Verhoef C</searchLink>; Department of Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Aalbers+AGJ%22">Aalbers AGJ</searchLink>; Department of Surgery, Antoni van Leeuwenhoek, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vincent+J%22">Vincent J</searchLink>; Department of Medical Oncology, Elkerliek Hospital, Helmond, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Buffart+TE%22">Buffart TE</searchLink>; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Werter+IM%22">Werter IM</searchLink>; Department of Medical Oncology, Rijnstate, Arnhem, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Douma+JAJ%22">Douma JAJ</searchLink>; Department of Medical Oncology, Frisius Medical Center, location Leeuwarden, Leeuwarden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bloemen+JG%22">Bloemen JG</searchLink>; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+JWA%22">Burger JWA</searchLink>; Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%227603616%22">International journal of radiation oncology, biology, physics</searchLink> [Int J Radiat Oncol Biol Phys] 2026 Jul 15; Vol. 125 (4), pp. 1008-1017. <i>Date of Electronic Publication: </i>2026 Jan 08.
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              Text: 2026 Jul 15
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