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Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis.

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Title: Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis.
Authors: Methatham T; Department of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan., Kimura N; Department of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan., Tomida S; Department of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan., Ishima T; Department of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan., Taguchi Y; Department of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan.; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, 329-0498, Japan., Uosaki H; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, 329-0498, Japan., Sakashita E; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, 329-0498, Japan., Endo H; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, 329-0498, Japan., Nagai R; Jichi Medical University, Tochigi, 329-0498, Japan. rnagai@jichi.ac.jp., Aizawa K; Department of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan. aizawa@jichi.ac.jp.; Clinical Pharmacology Center, Jichi Medical University Hospital, Tochigi, 329-0498, Japan. aizawa@jichi.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Jan 12; Vol. 16 (1), pp. 2367. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-32155-y