Asymmetric Synthesis of KRAS G12C Inhibitor MK-1084 via a Crystallization-Induced Diastereomer Transformation (CIDT).

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Title: Asymmetric Synthesis of KRAS G12C Inhibitor MK-1084 via a Crystallization-Induced Diastereomer Transformation (CIDT).
Authors: Li H; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Shang G; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Song ZJ; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wen X; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Chen Y; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tan L; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xiao KJ; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xu J; Department of Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Sather AC; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Kong J; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Belyk KM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Johnson HC; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hughes JME; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nawrat CC; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Kwan EE; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., He CQ; Department of Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lam YH; Department of Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhang J; Pharmaron Beijing Co., Ltd., Beijing 100176, China., Fan C; Pharmaron Beijing Co., Ltd., Beijing 100176, China., Song Z; Pharmaron Beijing Co., Ltd., Beijing 100176, China., Liu G; Shanghai SynTheAll Pharmaceutical Co., Ltd., Shanghai 201507, China., Wan B; Shanghai SynTheAll Pharmaceutical Co., Ltd., Shanghai 201507, China., Yuan Y; Shanghai SynTheAll Pharmaceutical Co., Ltd., Shanghai 201507, China., Maddess M; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yin J; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Source: Organic letters [Org Lett] 2026 Jan 23; Vol. 28 (3), pp. 923-928. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1523-7052
DOI:10.1021/acs.orglett.5c04646