Targeting the DKK1/CSF1 signaling axis to reprogram M2 macrophages and reverse chemoresistance in head and neck squamous cell carcinoma.

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Title: Targeting the DKK1/CSF1 signaling axis to reprogram M2 macrophages and reverse chemoresistance in head and neck squamous cell carcinoma.
Authors: Huang CS; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan; Department of Dentistry and Oral Health, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan., Huang CM; Department of Otolaryngology, Taitung Mackay Memorial Hospital, Taitung City 950408, Taiwan; Department of Nursing, Tajen University, Pingtung 90741, Taiwan., Ling HH; Division of Hemato-oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung & Chang Gung University, College of Medicine, Keelung 204, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan., Huang MS; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan; Department of Dentistry and Oral Health, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan., Hsieh MS; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan; Department of Dentistry and Oral Health, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan. Electronic address: Dr7d9eddd@gmail.com., Chen JH; Division of Medical Oncology and Hematology, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan. Electronic address: wen17140@mail.ndmctsgh.edu.tw.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2026 Mar 01; Vol. 218, pp. 107435. Date of Electronic Publication: 2026 Jan 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0720
DOI:10.1016/j.ejps.2026.107435