Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing.
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| Title: | Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing. |
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| Authors: | Haas J; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Schudy S; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Rauscher B; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Muñoz Verdú A; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Roßkopf S; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany., Reich C; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Donmez Yalcin G; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Yalcin A; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany.; Informatics for Life, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Seeger T; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany.; Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany., Dieterich C; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany.; Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany., Taft MH; Institute for Biophysical Chemistry, Hannover Medical School, Fritz-Hartmann-Centre for Medical Research, 30625, Hannover, Germany., Freichel M; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany.; Department of Pharmacology, University of Heidelberg, Heidelberg, Germany., Grimm D; German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany.; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, BioQuant, Heidelberg University, Heidelberg, Germany., Manstein D; Division for Structural Biochemistry, Hannover Medical School, 30625, Hannover, Germany., Backs J; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Frey N; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany.; Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany., Steinmetz L; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Genome Technology Center, Palo Alto, CA, USA., Meder B; Precision Digital Health Unit of the Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany. Benjamin.meder@med.uni-heidelberg.de.; Informatics for Life, Heidelberg, Germany. Benjamin.meder@med.uni-heidelberg.de.; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany. Benjamin.meder@med.uni-heidelberg.de. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2026 Feb; Vol. 18 (2), pp. 824-845. Date of Electronic Publication: 2026 Jan 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1757-4684 |
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| DOI: | 10.1038/s44321-025-00370-9 |
