PLGA nanoparticles restore acidic pH and degradative function to compromised lysosomes with Cy3-labeling providing enhanced tracking to lysosomes.
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| Title: | PLGA nanoparticles restore acidic pH and degradative function to compromised lysosomes with Cy3-labeling providing enhanced tracking to lysosomes. |
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| Authors: | Li J; Department of Chemistry, School of Arts and Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Wang T; Department of Chemistry, School of Arts and Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Lu W; Department of Basic and Translational Science, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Jishkariani D; Chemical and Nanoparticle Synthesis Core, University of Pennsylvania, Philadelphia, Pennsylvania, United States.; Department of Bioengineering, School of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Tsourkas A; Chemical and Nanoparticle Synthesis Core, University of Pennsylvania, Philadelphia, Pennsylvania, United States.; Department of Bioengineering, School of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Kaja S; Department of Ophthalmology, Loyola University Chicago, Health Sciences Campus, Maywood, Illinois, United States.; Department of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Health Sciences Campus, Maywood, Illinois, United States., Vining KH; Department of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.; Department of Materials Science and Engineering, School of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Thussananutiyakul J; Department of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.; Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Spence A; Department of Basic and Translational Science, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Nair RM; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Dunaief JL; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Mitchell CH; Department of Basic and Translational Science, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States. |
| Source: | American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 Feb 01; Vol. 330 (2), pp. C509-C523. Date of Electronic Publication: 2026 Jan 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1522-1563 |
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| DOI: | 10.1152/ajpcell.00494.2025 |
