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Disordered DNA-binding motif forms a modulation site for inhibiting the cancer immunotherapy target TREX1.

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Title: Disordered DNA-binding motif forms a modulation site for inhibiting the cancer immunotherapy target TREX1.
Authors: Huang KW; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Yu Tsai C; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Wu CY; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Lin WC; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei City, Taiwan., Wu MT; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Hsu KC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11011, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11011, Taiwan., Yu Yang C; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Chang IY; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Liu HM; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei City, Taiwan., Chu JW; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan., Hsiao YY; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Drug Development and Value Creation Research Center, Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Jan 14; Vol. 54 (2).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Disordered DNA-binding motif forms a modulation site for inhibiting the cancer immunotherapy target TREX1.
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  Data: <searchLink fieldCode="AU" term="%22Huang+KW%22">Huang KW</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+Tsai+C%22">Yu Tsai C</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CY%22">Wu CY</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+WC%22">Lin WC</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+MT%22">Wu MT</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+KC%22">Hsu KC</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11011, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11011, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+Yang+C%22">Yu Yang C</searchLink>; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+IY%22">Chang IY</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+HM%22">Liu HM</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+JW%22">Chu JW</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+YY%22">Hsiao YY</searchLink>; College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.; Drug Development and Value Creation Research Center, Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
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              Text: 2026 Jan 14
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