Astrocytic FKBP5 regulates neuroinflammation and cognitive outcomes in male mouse models of excitotoxic epilepsy.

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Title: Astrocytic FKBP5 regulates neuroinflammation and cognitive outcomes in male mouse models of excitotoxic epilepsy.
Authors: Gan YL; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112201, Taiwan., Lin SH; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Kang YP; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Zhou JZ; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Huang WH; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Sung PH; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Hung CC; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Hsu PC; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Ph.D. Program of Interdisciplinary Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Chu SY; Ph.D. Program of Interdisciplinary Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Shie FS; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 350401, Taiwan., Lee IH; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112201, Taiwan; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address: ihlee@vghtpe.gov.tw., Jeng CJ; Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department and Institute of Anatomy and Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address: cjjeng@nycu.edu.tw., Lee YH; Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address: yhlee3@nycu.edu.tw.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 Mar; Vol. 133, pp. 106278. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2139
DOI:10.1016/j.bbi.2026.106278