A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis.

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Title: A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis.
Authors: Dewani M; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Harvard Medical School, Boston, MA, USA., Mamidwar AR; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Graduate Program in Biomedical Research (MBR), Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA., Rawal M; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Bhingaradiya N; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Liu J; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Program in Genetics, Molecular and Cellular Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA., Pisal N; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Liu S; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Blank E; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Banerjee A; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Park D; Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA., Jiang C; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gupta A; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Katti SD; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Chen K; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Xia Z; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Nedumaran A; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Graduate Program in Biomedical Research (MBR), Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA., Karp J; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Lee S; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Karp JM; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Gao J; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. jgao@umass.edu.; Harvard Medical School, Boston, MA, USA. jgao@umass.edu.; Department of Biomedical Engineering, University of Massachusetts, Amherst, MA, USA. jgao@umass.edu., Joshi N; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. njoshi@bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. njoshi@bwh.harvard.edu., Zeng L; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA. Li.Zeng@tufts.edu.; Program in Genetics, Molecular and Cellular Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA. Li.Zeng@tufts.edu.; Program of Pharmacology and Experimental Therapeutics, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA. Li.Zeng@tufts.edu.; Department of Orthopaedics, Tufts Medicine, Boston, MA, USA. Li.Zeng@tufts.edu.
Source: Nature nanotechnology [Nat Nanotechnol] 2026 Mar; Vol. 21 (3), pp. 455-466. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1748-3395
DOI:10.1038/s41565-025-02101-0