A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis.
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| Title: | A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis. |
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| Authors: | Dewani M; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Harvard Medical School, Boston, MA, USA., Mamidwar AR; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Graduate Program in Biomedical Research (MBR), Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA., Rawal M; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Bhingaradiya N; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Liu J; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Program in Genetics, Molecular and Cellular Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA., Pisal N; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Liu S; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Blank E; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Banerjee A; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Park D; Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA., Jiang C; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gupta A; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Katti SD; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Chen K; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA., Xia Z; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Nedumaran A; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Graduate Program in Biomedical Research (MBR), Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA., Karp J; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA., Lee S; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Karp JM; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Gao J; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. jgao@umass.edu.; Harvard Medical School, Boston, MA, USA. jgao@umass.edu.; Department of Biomedical Engineering, University of Massachusetts, Amherst, MA, USA. jgao@umass.edu., Joshi N; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. njoshi@bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. njoshi@bwh.harvard.edu., Zeng L; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA. Li.Zeng@tufts.edu.; Program in Genetics, Molecular and Cellular Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA. Li.Zeng@tufts.edu.; Program of Pharmacology and Experimental Therapeutics, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA. Li.Zeng@tufts.edu.; Department of Orthopaedics, Tufts Medicine, Boston, MA, USA. Li.Zeng@tufts.edu. |
| Source: | Nature nanotechnology [Nat Nanotechnol] 2026 Mar; Vol. 21 (3), pp. 455-466. Date of Electronic Publication: 2026 Jan 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41535382 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Dewani+M%22">Dewani M</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mamidwar+AR%22">Mamidwar AR</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Graduate Program in Biomedical Research (MBR), Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rawal+M%22">Rawal M</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bhingaradiya+N%22">Bhingaradiya N</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Program in Genetics, Molecular and Cellular Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pisal+N%22">Pisal N</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Blank+E%22">Blank E</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Banerjee+A%22">Banerjee A</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Park+D%22">Park D</searchLink>; Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+C%22">Jiang C</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Katti+SD%22">Katti SD</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xia+Z%22">Xia Z</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nedumaran+A%22">Nedumaran A</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.; Graduate Program in Biomedical Research (MBR), Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Karp+J%22">Karp J</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Karp+JM%22">Karp JM</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+J%22">Gao J</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. jgao@umass.edu.; Harvard Medical School, Boston, MA, USA. jgao@umass.edu.; Department of Biomedical Engineering, University of Massachusetts, Amherst, MA, USA. jgao@umass.edu.<br /><searchLink fieldCode="AU" term="%22Joshi+N%22">Joshi N</searchLink>; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. njoshi@bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. njoshi@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Zeng+L%22">Zeng L</searchLink>; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA. Li.Zeng@tufts.edu.; Program in Genetics, Molecular and Cellular Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA. Li.Zeng@tufts.edu.; Program of Pharmacology and Experimental Therapeutics, Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA. Li.Zeng@tufts.edu.; Department of Orthopaedics, Tufts Medicine, Boston, MA, USA. Li.Zeng@tufts.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101283273%22">Nature nanotechnology</searchLink> [Nat Nanotechnol] 2026 Mar; Vol. 21 (3), pp. 455-466. <i>Date of Electronic Publication: </i>2026 Jan 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41535382 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41565-025-02101-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 455 Titles: – TitleFull: A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dewani M – PersonEntity: Name: NameFull: Mamidwar AR – PersonEntity: Name: NameFull: Rawal M – PersonEntity: Name: NameFull: Bhingaradiya N – PersonEntity: Name: NameFull: Liu J – PersonEntity: Name: NameFull: Pisal N – PersonEntity: Name: NameFull: Liu S – PersonEntity: Name: NameFull: Blank E – PersonEntity: Name: NameFull: Banerjee A – PersonEntity: Name: NameFull: Park D – PersonEntity: Name: NameFull: Jiang C – PersonEntity: Name: NameFull: Gupta A – PersonEntity: Name: NameFull: Katti SD – PersonEntity: Name: NameFull: Chen K – PersonEntity: Name: NameFull: Xia Z – PersonEntity: Name: NameFull: Nedumaran A – PersonEntity: Name: NameFull: Karp J – PersonEntity: Name: NameFull: Lee S – PersonEntity: Name: NameFull: Karp JM – PersonEntity: Name: NameFull: Gao J – PersonEntity: Name: NameFull: Joshi N – PersonEntity: Name: NameFull: Zeng L IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1748-3395 Numbering: – Type: volume Value: 21 – Type: issue Value: 3 Titles: – TitleFull: Nature nanotechnology Type: main |
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