Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

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Title: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.
Authors: Kim W; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Hu X; Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA., Kim K; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Applied Statistics, Gachon University, Seongnam, Republic of Korea., Chun S; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA., Orchard P; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Qiao D; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Ruczinski I; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Saferali A; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Aguet F; Illumina Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA., Antonacci-Fulton L; Department of Genetics, Washington University in St Louis, St Louis, MO, USA., Balte PP; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Bartz TM; Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA., Anamika WJ; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Zhou X; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Duan J; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Daviglus ML; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA., Doddapaneni H; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Dugan-Perez S; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Dutcher SK; Department of Genetics, Washington University in St Louis, St Louis, MO, USA., Frazar CD; University of Washington, Seattle, WA, USA., Gabriel SB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gharib SA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., Gupta N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hobbs BD; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Kasela S; New York Genome Center, New York, NY, USA., Loehr LR; Division of General Medicine and Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Metcalf GA; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Muzny DM; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Oelsner EC; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Smith J; Northwest Genomic Center, University of Washington, Seattle, WA, USA., Sofer T; Division of Sleep and Circadian Disorder, Brigham and Women's Hospital, Boston, MA, USA., Xu H; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Yu B; Department of Epidemiology, School of Public Health, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang D; Department of Medicine and Institute for Genomic Medicine, Irving Medical Center, Columbia University, New York, NY, USA., Ziniti J; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Barr RG; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA., Carson AP; Department of Medicine, University of Mississippi, Jackson, MS, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health at Houston, Houston, TX, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kalhan R; Department of Preventive Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kaplan R; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Lappalainen T; New York Genome Center, New York, NY, USA.; Department of Systems Biology, Columbia University, New York, NY, USA., London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, NC, USA., Morrison AC; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., O'Connor GT; Pulmonary Center, Boston University School of Medicine, Boston, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Departments of Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Silverman EK; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Manichaikul A; Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA. amanicha@virginia.edu., Cho MH; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. remhc@channing.harvard.edu.
Source: Genome biology [Genome Biol] 2026 Jan 15; Vol. 27 (1), pp. 28. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-760X
DOI:10.1186/s13059-025-03921-y