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Novel therapeutic potential of the PARP inhibitor talazoparib in synovial sarcoma and its combined effect with ATR inhibitor.

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Title: Novel therapeutic potential of the PARP inhibitor talazoparib in synovial sarcoma and its combined effect with ATR inhibitor.
Authors: Honda N; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Department of Molecular and Genomic Biomedicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Taniguchi H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. hirokazu_pc@nagasaki-u.ac.jp.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan. hirokazu_pc@nagasaki-u.ac.jp.; Clinical Oncology Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. hirokazu_pc@nagasaki-u.ac.jp., Ono S; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Hayashi F; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Imamura E; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Gyotoku H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Takemoto S; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Takazono T; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Ishimoto H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Sakamoto N; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Obase Y; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan., Masutani M; Department of Molecular and Genomic Biomedicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Nishino T; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Mukae H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Source: Discover oncology [Discov Oncol] 2026 Jan 15; Vol. 17 (1), pp. 279. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel therapeutic potential of the PARP inhibitor talazoparib in synovial sarcoma and its combined effect with ATR inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Honda+N%22">Honda N</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Department of Molecular and Genomic Biomedicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+H%22">Taniguchi H</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. hirokazu_pc@nagasaki-u.ac.jp.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan. hirokazu_pc@nagasaki-u.ac.jp.; Clinical Oncology Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. hirokazu_pc@nagasaki-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ono+S%22">Ono S</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+F%22">Hayashi F</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Imamura+E%22">Imamura E</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Gyotoku+H%22">Gyotoku H</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takemoto+S%22">Takemoto S</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takazono+T%22">Takazono T</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Ishimoto+H%22">Ishimoto H</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamoto+N%22">Sakamoto N</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Obase+Y%22">Obase Y</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Masutani+M%22">Masutani M</searchLink>; Department of Molecular and Genomic Biomedicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishino+T%22">Nishino T</searchLink>; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Mukae+H%22">Mukae H</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101775142%22">Discover oncology</searchLink> [Discov Oncol] 2026 Jan 15; Vol. 17 (1), pp. 279. <i>Date of Electronic Publication: </i>2026 Jan 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101775142 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-6011 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227306011%22">27306011 </searchLink><i>NLM ISO Abbreviation: </i>Discov Oncol <i>Subsets: </i>PubMed not MEDLINE
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