Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

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Title: Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.
Authors: Richter J; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany. Electronic address: jan.richter@uni-hildesheim.de., Hamm AO; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany., Lang T; Christoph-Dornier-Foundation for Clinical Psychology, Institute for Clinical Psychology Bremen, Bremen, Germany; Department for Psychology & Methods, Constructor University Bremen, Bremen, Germany., Gerlach AL; Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany., Melzig CA; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany., Helms A; Christoph-Dornier-Foundation for Clinical Psychology, Institute for Clinical Psychology Bremen, Bremen, Germany., Droste KL; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany., Goerigk S; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich, Germany; Department of Psychological Methodology, Charlotte Fresenius Hochschule, Munich, Germany., Straube B; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Rief W; Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany., Lueken U; German Center of Mental Health (DZPG) partner site Berlin-Potsdam, Berlin, Germany; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Alpers GW; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany., Helbig-Lang S; Department of Clinical Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
Source: Behaviour research and therapy [Behav Res Ther] 2026 Feb; Vol. 197, pp. 104946. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0372477 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-622X (Electronic) Linking ISSN: 00057967 NLM ISO Abbreviation: Behav Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-622X
DOI:10.1016/j.brat.2025.104946