Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

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Title: Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.
Authors: Richter J; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany. Electronic address: jan.richter@uni-hildesheim.de., Hamm AO; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany., Lang T; Christoph-Dornier-Foundation for Clinical Psychology, Institute for Clinical Psychology Bremen, Bremen, Germany; Department for Psychology & Methods, Constructor University Bremen, Bremen, Germany., Gerlach AL; Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany., Melzig CA; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany., Helms A; Christoph-Dornier-Foundation for Clinical Psychology, Institute for Clinical Psychology Bremen, Bremen, Germany., Droste KL; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany., Goerigk S; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich, Germany; Department of Psychological Methodology, Charlotte Fresenius Hochschule, Munich, Germany., Straube B; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Rief W; Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany., Lueken U; German Center of Mental Health (DZPG) partner site Berlin-Potsdam, Berlin, Germany; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany., Alpers GW; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany., Helbig-Lang S; Department of Clinical Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
Source: Behaviour research and therapy [Behav Res Ther] 2026 Feb; Vol. 197, pp. 104946. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0372477 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-622X (Electronic) Linking ISSN: 00057967 NLM ISO Abbreviation: Behav Res Ther Subsets: MEDLINE
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  Data: Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.
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  Data: <searchLink fieldCode="AU" term="%22Richter+J%22">Richter J</searchLink>; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany. Electronic address: jan.richter@uni-hildesheim.de.<br /><searchLink fieldCode="AU" term="%22Hamm+AO%22">Hamm AO</searchLink>; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+T%22">Lang T</searchLink>; Christoph-Dornier-Foundation for Clinical Psychology, Institute for Clinical Psychology Bremen, Bremen, Germany; Department for Psychology & Methods, Constructor University Bremen, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Gerlach+AL%22">Gerlach AL</searchLink>; Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Melzig+CA%22">Melzig CA</searchLink>; Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany; Department of Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Helms+A%22">Helms A</searchLink>; Christoph-Dornier-Foundation for Clinical Psychology, Institute for Clinical Psychology Bremen, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Droste+KL%22">Droste KL</searchLink>; Department of Experimental Psychopathology, University of Hildesheim, Hildesheim, Germany.<br /><searchLink fieldCode="AU" term="%22Goerigk+S%22">Goerigk S</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich, Germany; Department of Psychological Methodology, Charlotte Fresenius Hochschule, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Straube+B%22">Straube B</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kircher+T%22">Kircher T</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rief+W%22">Rief W</searchLink>; Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lueken+U%22">Lueken U</searchLink>; German Center of Mental Health (DZPG) partner site Berlin-Potsdam, Berlin, Germany; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Alpers+GW%22">Alpers GW</searchLink>; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Helbig-Lang+S%22">Helbig-Lang S</searchLink>; Department of Clinical Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
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  Data: <searchLink fieldCode="JN" term="%220372477%22">Behaviour research and therapy</searchLink> [Behav Res Ther] 2026 Feb; Vol. 197, pp. 104946. <i>Date of Electronic Publication: </i>2026 Jan 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0372477 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-622X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200057967%22">00057967 </searchLink><i>NLM ISO Abbreviation: </i>Behav Res Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb
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