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Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization.

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Bibliographic Details
Title: Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization.
Authors: Lulu-Shimron C; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Luo Z; National Cancer Center, National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences, and Peking Union Medical College Cancer Hospital, Beijing, China., Brekhman V; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Huang L; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Livneh I; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Kosako H; Division of Cell Signaling, Institute of Advanced Medical Sciences and Laboratory of Proteomics, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima 770-8503, Japan., Cohen-Kaplan V; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Ciechanover A; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 20; Vol. 123 (3), pp. e2529422123. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2529422123