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Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization.

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Title: Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization.
Authors: Lulu-Shimron C; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Luo Z; National Cancer Center, National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences, and Peking Union Medical College Cancer Hospital, Beijing, China., Brekhman V; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Huang L; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Livneh I; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Kosako H; Division of Cell Signaling, Institute of Advanced Medical Sciences and Laboratory of Proteomics, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima 770-8503, Japan., Cohen-Kaplan V; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel., Ciechanover A; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 20; Vol. 123 (3), pp. e2529422123. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization.
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  Data: <searchLink fieldCode="AU" term="%22Lulu-Shimron+C%22">Lulu-Shimron C</searchLink>; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.<br /><searchLink fieldCode="AU" term="%22Luo+Z%22">Luo Z</searchLink>; National Cancer Center, National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences, and Peking Union Medical College Cancer Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Brekhman+V%22">Brekhman V</searchLink>; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.<br /><searchLink fieldCode="AU" term="%22Livneh+I%22">Livneh I</searchLink>; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.<br /><searchLink fieldCode="AU" term="%22Kosako+H%22">Kosako H</searchLink>; Division of Cell Signaling, Institute of Advanced Medical Sciences and Laboratory of Proteomics, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima 770-8503, Japan.<br /><searchLink fieldCode="AU" term="%22Cohen-Kaplan+V%22">Cohen-Kaplan V</searchLink>; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.<br /><searchLink fieldCode="AU" term="%22Ciechanover+A%22">Ciechanover A</searchLink>; Rappaport-Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion- Israel Institute of Technology, Haifa 3109602, Israel.
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              Text: 2026 Jan 20
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