Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.

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Title: Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Authors: Dholakia V; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK., Quantrill JL; Department of Infectious Disease, Imperial College London, London, UK.; The Pirbright Institute, Woking, UK., Richardson SAS; The Pirbright Institute, Woking, UK., Pankaew N; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Brown MD; Department of Infectious Disease, Imperial College London, London, UK., Yang J; The Pirbright Institute, Woking, UK., Capelastegui F; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK., Masonou T; Great Ormond Street UCL Institute of Child Health, London, UK., Case KM; Great Ormond Street UCL Institute of Child Health, London, UK., Ajeian J; Great Ormond Street UCL Institute of Child Health, London, UK., Woodall MNJ; Great Ormond Street UCL Institute of Child Health, London, UK., Magill C; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Freimanis G; The Pirbright Institute, Woking, UK., McCarron A; The Pirbright Institute, Woking, UK., Staller E; Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK., Sheppard CM; Department of Infectious Disease, Imperial College London, London, UK., Brown IH; The Pirbright Institute, Woking, UK., Murcia PR; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Smith CM; Great Ormond Street UCL Institute of Child Health, London, UK., Iqbal M; The Pirbright Institute, Woking, UK., Digard P; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Barclay WS; Department of Infectious Disease, Imperial College London, London, UK., Pinto RM; The Roslin Institute, University of Edinburgh, Edinburgh, UK. rpinto2@exseed.ed.ac.uk., Peacock TP; Department of Infectious Disease, Imperial College London, London, UK. tom.peacock@pirbright.ac.uk.; The Pirbright Institute, Woking, UK. tom.peacock@pirbright.ac.uk., Goldhill DH; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK. dgoldhill@rvc.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jan 16; Vol. 17 (1), pp. 1603. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-68306-6