Bioengineered extracellular vesicles escape lysosomal degradation and deliver Tet-PKM2 for macrophage immunometabolic reprogramming and periodontitis treatment.

Saved in:
Bibliographic Details
Title: Bioengineered extracellular vesicles escape lysosomal degradation and deliver Tet-PKM2 for macrophage immunometabolic reprogramming and periodontitis treatment.
Authors: Zhang WJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Tian BM; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Li F; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Li X; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Wu RX; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Yin Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Wang J; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China., Deng DK; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Chen YZ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Wang HY; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Du YX; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Wang X; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Xiao Y; School of Medicine and Dentistry & Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD, 4222, Australia.; The Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), Brisbane, QLD, 4000, Australia., He XT; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China., Chen FM; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, PR China.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China.
Source: Bioactive materials [Bioact Mater] 2026 Jan 06; Vol. 59, pp. 607-628. Date of Electronic Publication: 2026 Jan 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ke Ai Publishing Country of Publication: China NLM ID: 101685294 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-199X (Electronic) Linking ISSN: 2452199X NLM ISO Abbreviation: Bioact Mater Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2452-199X
DOI:10.1016/j.bioactmat.2026.01.002