AKR1C3 promotes aerobic glycolysis in hepatic stellate cells via the AKT/mTOR pathway to induce liver fibrosis.

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Title: AKR1C3 promotes aerobic glycolysis in hepatic stellate cells via the AKT/mTOR pathway to induce liver fibrosis.
Authors: Ran T; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Zhang QX; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Wu HY; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Feng S; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Han L; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Qin Y; Department of Gastroenterology, Yanhe Tujia autonomous County People's Hospital, Yanhe 565300, China., Lin GY; Department of Cardiology, Guiqian International General Hospital, Guiyang, Guiyang 550000, China., Zhang Y; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China; Department of Gastroenterology, The Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang 550000, China., Li SL; Department of Vascular Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Chen JY; Clinical Trials Center, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Zhou YM; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China., Cai SQ; Department of Gastroenterology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China., Zhao XK; Department of Infectious Disease, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China. Electronic address: zhaoxueke1@163.com.
Source: Cellular signalling [Cell Signal] 2026 May; Vol. 141, pp. 112369. Date of Electronic Publication: 2026 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-3913
DOI:10.1016/j.cellsig.2026.112369