SGLT2 inhibitor-induced glycosuria improves steatotic liver disease in parallel with enhanced ureagenesis in ob/ob mice.

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Title: SGLT2 inhibitor-induced glycosuria improves steatotic liver disease in parallel with enhanced ureagenesis in ob/ob mice.
Authors: Kidoguchi S; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: s.kidoguchi@jikei.ac.jp., Kitada K; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan., Morishita A; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan., Tsuji Y; Department of Biomedical Molecular Sciences, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Ohsaki H; Department of Medical Biophysics, Kobe University Graduate School of Health Science, Kobe, Japan., Yamazaki D; Division of Nephrology and Hypertension, Osaka City General Hospital, Osaka, Japan., Morikawa T; Division of Nephrology and Hypertension, Osaka City General Hospital, Osaka, Japan., Konishi Y; Division of Nephrology and Hypertension, Osaka City General Hospital, Osaka, Japan., Kobara H; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan., Yokoo T; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Titze J; Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore; )Division of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nuremberg, Germany; Division of Nephrology, Duke University Medical Center, Durham, NC, USA., Takahashi K; Center for Joint Research Facilities Support, Research Promotion and Support Headquarters, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Nishiyama A; Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Source: Journal of pharmacological sciences [J Pharmacol Sci] 2026 Feb; Vol. 160 (2), pp. 122-131. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article
Journal Info: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1347-8648
DOI:10.1016/j.jphs.2025.12.006